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Histamine Intolerance and ADHD: Is there a connection?

At Bradley’s Fish, we often talk about the benefits of eating nutrient-rich seafood, but occasionally we come across interesting discussions about how diet, allergies and even histamine levels can influence health in unexpected ways. One topic that has been gaining attention is the possible link between histamine intolerance and Attention Deficit Hyperactivity Disorder (ADHD). While we are not medical professionals, we have looked at some of the research and expert opinions suggesting that histamine – a compound involved in immune responses – might affect brain health. Histamine intolerance occurs when the body struggles to break down excess histamine, leading to symptoms such as brain fog, irritability, sleep disruption, mood swings and anxiety. According to some medical experts these symptoms can overlap with, or potentially worsen, ADHD.

What does the research say?

 Some studies have found that allergies and histamine-related issues might be connected to ADHD symptoms. For instance, a 2018 study in Scientific Reports highlighted that children with allergic conditions, like eczema or hay fever, were more likely to display ADHD traits. Other research has explored how histamine-regulating enzymes (like HNMT) and reactions to food additives can influence hyperactivity and attention levels. There’s also growing evidence that neuroinflammation – a type of inflammation in the brain – could play a role in ADHD and histamine release from mast cells (immune cells) might contribute to this process.

 Could diet make a difference?

Dietary habits are known to affect both histamine levels and brain function. Foods high in histamine – such as aged cheese, processed meats, and certain fermented products – can trigger reactions in those who are sensitive. Fish, on the other hand, can be an excellent source of nutrients like omega-3 fatty acids, which have been linked to improved brain health and may support focus and mood.

 Research into omega-3 fatty acids and ADHD is still growing, and more studies are anticipated to focus on how different types of omega-3s, like EPA and DHA, affect ADHD differently. The research so far suggests omega-3 fatty acids found in oily fish, like salmon and mackerel, might benefit children and adults with ADHD. While this doesn’t mean histamine intolerance causes ADHD, it does highlight the potential of dietary approaches to support overall mental wellbeing.

 Did you know that freezing fish at sea can make a real difference for people with histamine intolerance?

 At Bradley’s Fish, we understand that managing histamine levels can make choosing seafood tricky. That’s why our frozen-at-sea range is such a game-changer – the fish is frozen immediately after it’s caught, locking in freshness and helping to keep histamine levels lower. This means you can enjoy your favourite fish with confidence and peace of mind.

 Which fish are best for histamine intolerance?

We focus on species that go from catch to freezing in the shortest time possible, as prolonged storage in a “fresh” chilled state can lead to a natural rise in histamine levels.

 Some of our top frozen-at-sea recommendations include:

• Haddock Fillets Finest

• Hake Fillets

• Whole Mackerel

• Cod Fillet Finest (skin off)

• Cod Loin

• Coley Fillets

• Redfish

• Coho Salmon Fillet

 It’s important to remember that research into the link between histamine intolerance and ADHD is still in its early stages. Everyone’s experience with ADHD or food sensitivities is unique and what works for one person may not work for another. At Bradley’s Fish, we believe that good nutrition is a cornerstone of overall wellbeing. While we can’t make medical claims, incorporating low-histamine foods such as fresh fish frozen at sea and nutrient-rich fish into your diet can be a simple step towards supporting your body and mind.